What causes ATTR amyloidosis?
There are 2 types of ATTR amyloidosis
Hereditary ATTR amyloidosis
Hereditary ATTR amyloidosis is passed down through family members (genetically inherited). In hereditary ATTR amyloidosis, a mutation in the TTR gene results in an abnormal, misfolded TTR protein leading to amyloid accumulation in the body. If one parent has hereditary ATTR amyloidosis, there is a 50% chance their child will inherit the mutation. However, not everyone who inherits the mutation will go on to develop symptoms of ATTR amyloidosis.
Wild-type ATTR amyloidosis
Wild-type ATTR amyloidosis is not inherited, but is instead caused when TTR proteins become unstable, often as a result of age, causing abnormal TTR.
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